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RS 67333 hydrochloride

CAS No. 168986-60-5

RS 67333 hydrochloride( RS 67333 HCl | RS 67333 (hydrochloride) )

Catalog No. M27698 CAS No. 168986-60-5

potent and highly selective 5-HT4 partial agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RS 67333 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    potent and highly selective 5-HT4 partial agonist.
  • Description
    potent and highly selective 5-HT4 partial agonist.(In Vitro):RS 67333 hydrochloride exhibits affinities for the sigma 1 (pKi = 8.9) and sigma 2 (pKi = 8.0) binding sites. At the 5-HT4 receptor mediating relaxation of the carbachol-precontracted oesophagus, RS 67333 hydrochloride acts as a potent (pEC50 of 8.4), partial agonists (intrinsic activities, with respect to 5-HT is 0.5) with respect to 5-HT .
  • In Vitro
    RS 67333 hydrochloride does exhibit affinities for the sigma 1 (pKi = 8.9) and sigma 2 (pKi = 8.0) binding sites. At the 5-HT4 receptor mediating relaxation of the carbachol-precontracted oesophagus, RS 67333 hydrochloride acts as a potent (pEC50 of 8.4), partial agonists (intrinsic activities, with respect to 5-HT is 0.5) with respect to 5-HT.
  • In Vivo
    ——
  • Synonyms
    RS 67333 HCl | RS 67333 (hydrochloride)
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    c-Fgr|Lyn|Hck|Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    168986-60-5
  • Formula Weight
    389.36
  • Molecular Formula
    C19H30Cl2N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (128.42 mM)
  • SMILES
    Cl.CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Weir MC, et al. Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo. ACS Chem Biol. 2018 Jun 15;13(6):1551-1559.
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